Electrical stimulation enhances peripheral nerve regeneration after crush injury in rats
نویسندگان
چکیده
منابع مشابه
Electrical Stimulation Enhances Reinnervation After Nerve Injury.
Electrical muscle stimulation following peripheral nerve injury has been a controversial method of treatment due primarily to the inconsistent literature surrounding it. In this presentation transcript I outline ongoing experiments investigating a clinically translatable daily muscle stimulation paradigm in rats following nerve injury. Results show that reinnervation of muscle and functional be...
متن کاملErythropoietin promotes functional recovery and enhances nerve regeneration after peripheral nerve injury in rats.
BACKGROUND AND PURPOSE EPO has been shown to have beneficial effects in a variety of CNS injury models. The purpose of this study was to evaluate the effects of EPO on nerve regeneration and functional recovery in a rat model of peripheral nerve surgery. MATERIALS AND METHODS The sciatic nerve of the rat with a 10-mm defect was bridged with a silicone rubber tube. Forty adult male Sprague-Daw...
متن کاملElectrical stimulation for promoting peripheral nerve regeneration.
The peripheral nervous system has the intrinsic capacity to regenerate axons into target tissues, and peripheral nerves severely damaged or transected can be reconstructed by microsurgical techniques. The aim of peripheral nerve surgery is to pave way for fast and most possible thorough functional recovery. However, full functional recovery is rarely seen and several reasons for this have alrea...
متن کاملThirty minutes of low intensity electrical stimulation promotes nerve regeneration after sciatic nerve crush injury in a rat model.
We investigated whether electrical stimulation (ES) applied directly for 30 minutes after crushing injury to the sciatic nerves of rats could improve nerve regeneration. Two groups of animals were used in this study (n = 20 each): the ES group received 30 minutes of low intensity ES (20 Hz pulse rate, 2 uA amplitude) immediately after a standard crush injury, while the control group received no...
متن کاملElectrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury.
Although injured peripheral axons are able to regenerate, functional recovery is usually poor after nerve transection. In this study we aim to elucidate the role of neuronal activity, induced by nerve electrical stimulation and by exercise, in promoting axonal regeneration and modulating plasticity in the spinal cord after nerve injury. Four groups of adult rats were subjected to sciatic nerve ...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2013
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2013.1395